Starting with a few milligrams of purified protein, we will run a crystallization screen using either the screening kits from
or the high throughput screening methods developed by the
in Buffalo, New York.
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Bone, R., Lu, T., Illig, C.R., Soll, R.M., Spurlino, J.C.: Structural Analysis of Thrombin Complexed with Potent Inhibitors Incorporating a Phenyl Group as a Peptide Mimetic and Aminopyridines as Guanidine Substitutes. J.Med.Chem. v41 pp.2068-2075 (1998)Jmol: http://www.jmol.org/